Intrathecal administration

Injection directly into the cerebrospinal fluid (CFS) ensures complete CNS bioavailability for drugs that cannot cross the blood-brain barrier.


This dosage route is used to treat serious CNS infections such as meningitis and ventriculitis, and with such agents as mepivacaine and prilocaine for spinal anesthesia. Drugs injected intrathecally initially distribute into approximately 140 ml of CSF, thus producing high concentrations in the CNS with low risk of systemic toxicity.

Intrathecal administration
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