Effi cacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke
The Lancet -October2014 - http://dx.doi.org/10.1016/S0140-6736(14)61121-1
High blood pressure is associated with poor outcome after stroke. Whether blood pressure should be lowered early after stroke, and whether to continue or temporarily withdraw existing antihypertensive drugs, is not known. We assessed outcomes after stroke in patients given drugs to lower their blood pressure.
Changing the diagnostic criteria for myocardial infarction in patients with a suspected heart attack affects the measurement of 30 day mortality but not long term survival
PMC1767392 : To explore the effects of alternative methods of defining myocardial infarction on the numbers and survival patterns of patients identified as having sustained a confirmed myocardial infarct.
Comparative effectiveness of adjunctive devices in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention of native vessels
PMC3313863 : : During percutaneous coronary intervention (PCI), dislodgement of atherothrombotic material from coronary lesions can result in distal embolization, and may lead to increased major adverse cardiovascular events (MACE) and mortality.
PMC2537993 : Myocardial infarction is a key component of the burden of cardiovascular disease. The assessment of the incidence and case fatality of myocardial infarction are important determinants of the decline in coronary disease mortality. The change in biomarker used to diagnose myocardial infarction raise a number of methodological, clinical, and public health challenges, which are discussed herein.
The Effect of Tobacco Control Measures during a Period of Rising Cardiovascular Disease Risk in India
PMC3706364 : We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade.
Spironolactone for Heart Failure with Preserved Ejection Fraction
Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated the effects of spironolactone in patients with heart failure and a preserved left ventricular ejection fraction.
Management and Outcomes of Renal Disease and Acute Myocardial Infarction
PMC2930897 : Contemporary trends in the management and outcomes of patients with chronic kidney disease who develop an acute myocardial infarction have not been adequately described, particularly from the more generalizable perspective of a population-based investigation.
Early identification and delay to treatment in myocardial infarction and stroke: differences and similarities
PMC2944143 : The two major complications of atherosclerosis are acute myocardial infarction (AMI) and acute ischemic stroke. Both are life-threatening conditions characterised by the abrupt cessation of blood flow to respective organs, resulting in an infarction. Depending on the extent of the infarction, loss of organ function varies considerably.
Effect of β blockers on mortality after myocardial infarction in adults with COPD: population based cohort study of UK electronic healthcare records
PMC3898388 : To investigate whether the use and timing of prescription of β blockers in patients with chronic obstructive pulmonary disease (COPD) having a first myocardial infarction was associated with survival and to identify factors related to their use.
Long-Term Clinical Outcomes according to Initial Management and Thrombolysis In Myocardial Infarction Risk Score in Patients with Acute Non-ST-Segment Elevation Myocardial Infarction
PMC2799982 : There is still debate about the timing of revascularization in patients
with acute non-ST-segment elevation myocardial infarction (NSTEMI). We analyzed the long-term clinical outcomes of the timing of revascularization in patients with acute NSTEMI obtained from the Korea Acute Myocardial Infarction Registry (KAMIR).
PMC2642482 : Myocardial infarction is the most common cause of cardiac injury and results in acute loss of a large number of myocardial cells. Because the heart has negligible regenerative capacity, cardiomyocyte death triggers a reparative response that ultimately results in formation of a scar and is associated with dilative remodeling of the ventricle. Cardiac injury activates innate immune mechanisms initiating an inflammatory reaction.
Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
PMC3182906 : Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction.