Structure and composition of pulmonary arteries, capillaries and veins
PMC3630377 : The pulmonary vasculature is comprised of three anatomic compartments connected in series: the arterial tree, an extensive capillary bed, and the venular tree. Although in general this vasculature is thin-walled, structure is nonetheless complex. Contributions to structure (and thus potentially to
function) from cells other than endothelial and smooth muscle cells as well as those from the extracellular matrix should be considered.
PMC2939531 : Interstitial lung disease (ILD) in infants and children comprises a large spectrum of rare respiratory disorders that are mostly chronic and associated with high morbidity and mortality. These disorders are characterized by inflammatory
and fibrotic changes that affect alveolar walls. Typical features of ILD include dyspnea, diffuse infiltrates on chest radiographs, and abnormal pulmonary function tests with restrictive ventilatory defect and/or impaired gas exchange.
Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD
Retrospective studies have shown that statins decrease the rate and severity of exacerbations, the rate of hospitalization, and mortality in chronic obstructive pulmonary disease (COPD)
Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome
NEW ENGLAND JOURNAL OF MEDICINE
In the acute respiratory distress syndrome (ARDS), inflammation in the lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy- 3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory responses.
Sex Differences and Sex Steroids in Lung Health and Disease
PMC3365843 : Sex differences in the biology of different organ systems and the influence of sex hormones in modulating health and disease are increasingly relevant in clinical and research areas. Although work has focused on sex differences and sex hormones in cardiovascular, musculoskeletal, and neuronal
systems, there is now increasing clinical evidence for sex differences in incidence, morbidity, and mortality of lung diseases including allergic diseases (such as asthma), chronic obstructive pulmonary disease, pulmonary fibrosis, lung cancer, as well as pulmonary hypertension.
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