The determinants of transverse tubular volume in resting skeletal muscle
The transverse tubular (t)-system of skeletal muscle couples sarcolemmal electrical excitation with contraction deep within the fibre. Exercise, pathology and the composition of the extracellular fluid (ECF) can alter t-system volume (t-volume). T-volume changes are thought to contribute to fatigue, rhabdomyolysis and disruption of excitation–contraction coupling.
Documento Adobe Acrobat 1.1 MB
Ionotropic glutamate receptors: alive and kicking
Up until that point, structure–function studies focused on examining the isolated extracellular domains of the iGluR, such as the ligand-binding pocket (LBD) and amino-terminal (NTD).
Ionotropic glutamate receptors.pdf
Documento Adobe Acrobat 217.6 KB
Structure and gating of tetrameric glutamate receptors
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that open their ion-conducting pores in response to the binding of agonist glutamate. In recent years, significant progress has been achieved in studies of iGluRs by determining numerous structures of isolated water-soluble ligand-binding and amino-terminal domains, as well as solving the first crystal structure of the full-length AMPA receptor in the closed, antagonist-bound state.
Structure and gating of tetrameric gluta
Documento Adobe Acrobat 803.0 KB
Glutamate receptor pores
Glutamate receptors are ligand-gated ion channels that mediate fast excitatory synaptic transmission throughout the central nervous system. Functional receptors are homo- or heteromeric tetramers with each subunit contributing a re-entrant pore loop that dips into the membrane from the cytoplasmic side
Glutamate receptor pores.pdf
Documento Adobe Acrobat 763.6 KB