1. Differentiate between a complete and incomplete spinal cord injury.
2. Describe the clinical presentation of complete and incomplete spinal cord syndromes.
3. State the two major considerations for surgical treatment of spinal cord injuries.
4. Recognize unique surgical considerations in high cervical spinal cord injuries and unstable thoracic injuries.
A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury
Pubmed : PMC3143488
Cell transplantation therapies have become a major focus in pre-clinical research as a promising strategy for the treatment of spinal cord injury (SCI). In this article, we systematically review the available pre-clinical literature on the most commonly used cell types in order to assess the body of evidence that may support their translation to human SCI patients.
Antioxidant Therapies for Acute Spinal Cord Injury
Summary: One of the most investigated molecular mechanisms involved in the secondary pathophysiology of acute spinal cord injury (SCI) is free radical-induced, iron-catalyzed lipid peroxidation (LP) and protein oxidative/nitrative damage to spinal neurons, glia, and microvascular cells.
Disability, atrophy and cortical reorganization following spinal cord injury
The impact of traumatic spinal cord injury on structural integrity, cortical reorganization and ensuing disability is variable and may depend on a dynamic interaction between the severity of local damage and the capacity of the brain for plastic reorganization.
Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model
Background: The aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression. Its histo-pathological and behavioural outcomes are extensively similar to human SCI.
NEUROTROPHIC FACTORS IN COMBINATORIAL APPROACHES FOR SPINAL CORD REGENERATION
Axonal regeneration is inhibited by a plethora of different mechanisms in the adult central nervous system (CNS). While neurotrophic factors have been shown to stimulate axonal growth in numerous animal models of nervous system injury.
Nursing bedside education and care management time during
in patient spinal cord injury rehabilitation.
Background: Nurses are an integral part of the spinal cord injury (SCI) rehabilitation team and provide significant education to the patient and family about the intricacies of living with SCI.
Pharmacological evidence for a role of peroxynitrite in the pathophysiology of spinal cord injury
Evidence suggests that the reactive oxygen species peroxynitrite (PN) is an important player in the pathophysiology of acute spinal cord injury (SCI). In the present study, we examined the ability of tempol, a catalytic scavenger of PN-derived free radicals, to alleviate oxidative damage..
Plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transection
Complete thoracic (T) spinal cord injury (SCI) above the T6 level typically results in autonomic dysreflexia, an abnormal hypertensive condition commonly triggered by nociceptive stimuli belowthe level of SCI.
Recovery of control of posture and locomotion after a spinal cord injury: solutions staring us in the face
Over the past 20 years, tremendous advances have been made in the field of spinal cord injury research. Yet, consumed with individual pieces of the puzzle, we have failed as a community to grasp the magnitude of the sum of our findings.
Transplantation-Mediated Strategies to Promote Axonal Regeneration following Spinal Cord Injury
Devastating central nervous system injuries and diseases continue to occur in spite of the tremendous efforts of various prevention programs. The enormity of and annual escalation of healthcare costs due to them require that therapeutic strategies be responsibly developed.